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Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution containers permit. Solutions for injection showing evidence of precipitation should not be used.

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Status epilepticus: Pentobarbital can be administered in refractory status epilepticus according to the AAN guidelines for convulsive status epileptics.

Administer under close supervision and Con a setting where vital signs can be monitored; BP, respiration, and cardiac function maintained; and equipment for resuscitation and artificial ventilation are readily available. (See Respiratory and Cardiovascular Effects under Cautions.)

Retrospective, case-controlled studies indicate an association between maternal ingestion of barbiturates and a higher than expected incidence of fetal abnormalities.

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